Inova Center for Wellness and Metabolic Health, 2740 Prosperity Avenue, Fairfax, USA
Opinion
Dismal Octet and Other Frightening Diabetes Stories: An Overview of Type 2 Diabetes Mellitus' Pathophysiology
Author(s): Dion Kelly*
Type 2 Diabetes Mellitus (T2DM) unfolds as a complex narrative of metabolic dysfunction, weaving a chilling tale involving the "Dismal Octet" - a group of interconnected physiological derangements leading to glucose homeostasis disruption. This overview delves into the ominous storyline of T2DM pathophysiology, exploring the intricate characters and molecular plot twists that contribute to its onset and progression. The narrative begins with a cast of characters that includes insulin resistance, beta-cell dysfunction, increased hepatic glucose production, and altered incretin dynamics, forming the harrowing Dismal Octet. As these characters take center stage, their collective actions unfold a sinister plot, driving aberrations in glucose metabolism and paving the way for the development of T2DM. The molecular drama extends beyond the Dismal Octet, encompassing oxidative stre.. View More»
DOI:
10.35248/2155-6156.10001069
