Medicine of the Ministry of Education, School of Aerospace Medicine, China
Short Communication
Weightlessness Induces Hippocampal Insulin Resistance and Cognitive Impairment
Author(s): Fang Gaol*
Weightlessness, as experienced during space travel or prolonged bed rest, has been associated with various physiological changes, including alterations in metabolism and cognition. However, the impact of weightlessness on hippocampal insulin sensitivity and cognitive function remains poorly understood. In this study, we investigated the effects of simulated weightlessness on hippocampal insulin resistance and cognitive performance in a rodent model. Male rats were subjected to hindlimb unloading (HU) to simulate weightlessness for 21 days, while control rats remained weightbearing. Our findings reveal that simulated weightlessness induced hippocampal insulin resistance, as evidenced by impaired insulin signaling and reduced glucose uptake in the hippocampi of HU rats compared to controls. Additionally, HU rats exhibited deficits in spatial learning and memory tasks, indicative of cog.. View More»
DOI:
10.35248/2155-6156.10001087
