Kulvinder Kaur Centre for Human Reproduction, 721, GTB Nagar, Jalandhar, 144001 Punjab, India
Research Article
Targeting Macrophage Polarization for Therapy of Diabesity??The Feasibility of Early Improvement of Insulin Sensitivity and Insulin Resistance: A
Comprehensive Systematic Review
Author(s): Kulvinder Kochar Kaur*, Gautam Allahbadia and Mandeep Singh
The incidence of obesity is increasing in mammoth proportions so much so that associated comorbidity T2DM incidence is increasing markedly that we had to coin a term Diabesity to target both together. Earlier trying to review etiopathogenesis of both obesity and type 2 DM we found that whatever drugs that are formulated usually do not work with some complications and till now other than bariatric surgery we have no permanent cure for long term maintenance.Further T2DM might be a disease of 2 etiopathogenesis, namely inflammatory, as well as metabolic.Although metabolic inflammation has the properties of being systemic, their common initiating point is tissue resident macrophages, whose successful physiological or abnormal pathological adaptation to its microenvironment dictates disease course as well as severity. Earlierv we reviewed macrophage polarization in case of non alcoholic fa.. View More»
DOI:
10.35248/2155-6156.21.12.867
