Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Perspective
Patients with type 2 diabetes mellitus have varying relationships between mean HbA1c and HbA1c variability in terms of issues related to their diabetes
Author(s): Herno Chen*
Objectives: To investigate the distinct effects of variation in HbA1c and mean HbA1c on diabetes-related complications in type 2 diabetes patients.
Methods: In a Diabetes Shared Care Program, 1869 type 2 diabetes patients were followed up for an average of 9.5 years. Mean HbA1c (HbA1cmean) and standard deviation of HbA1c (HbA1c-SD) were determined during the initial 5 years. Nephropathy (urine albumin-to-creatinine ratio [UACR] greater than 300 mg/g and doubling of serum creatinine), any and advanced retinopathy, and all-cause and cardiovascular disease mortality were among the clinical outcomes.
Results: UACR > 300 mg/g (Hazard ratio [HR] 1.308 [95% confidence interval [CI], 1.194–1.433]), any retinopathy (HR 1.274 [1.171–1.385]), and advanced retinopathy (HR 1.237 [1.014–1.509]) were all inde.. View More»
DOI:
10.35248/2155-6156.1000997
