Woman's Health Research Department, Woman's Hospital, Baton Rouge, LA, United States
Mini Review
Maternal Glycemia is Associated with the Perinatal Outcome in Clinical
Assessments of Insulin Action in Late Pregnancy in Women at Risk for Gestational
Diabetes
Author(s): Loren Ekind-Hirsch*
Objective: We prospectively evaluated differences in fasting- and oral glucose tolerance test (OGTT)-derived indices of insulin action in Caucasian (Cau) and African-American (AA) pregnant women and compared them with obstetric outcomes.
Study design: IRB-approved prospective study in 171 pregnant women undergoing a 3-h OGTT. Mathematical modeling was used to evaluate insulin response, insulin activity and glucose tolerance in fasting and postglucose ingestion state. Insulin sensitivity indices derived from fasting (HOMA-IR) and glucose-stimulated values (SIOGTT) were compared. An insulin sensitivity-secretion index (IS-SI) was calculated from the product of the SIOGTT and early-phase insulin secretion.
Results: Forty-nine patients had gestational diabetes (GDM), 28 had gestational impaired glucose tolerance (GIGT).. View More»
DOI:
10.35248/2155-6156.10001001
