Department of Physiology & Molecular Biology, Bangladesh University of Health Sciences, Dhaka, Bangladesh
Hypothesis
Serum free IGF-1 and IGFBP-1 levels are linked to insulin sensitivity and insulin secretory abnormalities in Bangladeshi type 2 diabetes patients.
Author(s): Mohammad Faruque*
Objectives: It is possible that insulin resistance and dysfunction in B-cell secretory function are associated with serum free insulin like growth factors-1 (IGF-1) and insulin like growth factor binding protein-1 (IGFBP-1). The purpose of this study is to determine whether type 2 diabetics in a Bangladeshi population have two distinct associations with IGF-1 and IGFBP-1.
Methods: Sixty-eight people with type 2 diabetes (DM) and 61 healthy controls without a family history of diabetes or prediabetes are studied alongside age, sex, and BMI-matched controls. The standard ELISA method is used to measure insulin, free IGF-1, and IGFBP-1. HOMA-CIGMA software uses fasting glucose and fasting insulin to calculate insulin secretory capacity (HOMA B) and sensitivity (HOMA S).
Results: The study groups did not significantly .. View More»
DOI:
10.35248/2155-6156.1000992
