South Wales University, Diploma MSc, United Kingdom
Review Article
C-Reactive Protein, a Surrogate for Diabetes Nephropathy: A Systematic Review
Author(s): Porman P Maduna*
Over 415 million people have diabetes mellitus (DM) and among them, 40% develops diabetes nephropathy (DN). Because of DN, 5 to 15% end up developing end-stage renal failure (ESRF). Diagnosis of DN includes; urinary albumin excretion (UAE) persistently at 30 mg/day to 300 mg/day, and greater than 300 mg/day, in microalbuminuria and macroalbuminuria respectively. Another method is the glomerular filtration rate (GFR) or creatinine clearance rate < 60 ml/min, as calculated from a simplified MDRD formula.
DN follows a very complex pathogenic process. However, a large body of evidence demonstrates that, inflammation is key to events related to the development and progression of DN. Most epidemiologic reports based on observational studies investigating the hypotheses that inflammation is a risk factor in the development of DM and DN, have constantly agreed on a relationship f.. View More»
DOI:
10.35248/2155-6156.21.12.882
