All India Institute of Medical Sciences, New Delhi, India
Editorial
Overcoming ?-Cell Dysfunction in Type 2 Diabetes Mellitus
Author(s): Rajesh Kumar*
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder
characterized by insulin resistance and progressive pancreatic ?-cell
dysfunction. While insulin resistance often initiates the disease, it is the
failure of ?-cells to compensate that drives hyperglycemia and disease
progression. Preserving or restoring ?-cell function is thus a critical goal
in T2DM management. This review outlines the underlying mechanisms of
?-cell dysfunction, including glucotoxicity, lipotoxicity, oxidative stress, and
inflammation. It also explores current and emerging strategies to overcome
?-cell failure, such as lifestyle interventions, pharmacological agents,
incretin-based therapies, islet regeneration, and novel cellular approaches.
Targeting ?-cell dysfunction offers the potential to halt or even reverse
T2DM, paving the way for personalized and durable therapeutic strategies... View More»
