Department of Biochemistry, Majhigariani Institute of Technology and Science, BPUT University of Rourkela, India
Opinion
Targeting Insulin Receptor Endocytosis as a Therapeutic Strategy for Insulin Resistance
Author(s): Santos Meher*
Insulin resistance, characterized by impaired cellular response to insulin, is a hallmark of type 2 diabetes mellitus and a precursor to various metabolic disorders. Despite significant advancements in understanding its pathogenesis, effective therapeutic interventions remain elusive. Recent studies have shed light on the role of insulin receptor endocytosis in modulating insulin signaling and sensitivity. This process, crucial for the internalization and subsequent degradation or recycling of insulin receptors, has emerged as a potential target for therapeutic intervention in insulin resistance. This review explores the intricate mechanisms underlying insulin receptor endocytosis and its contribution to insulin resistance. We discuss the dysregulation of endocytic pathways observed in insulin-resistant states, including alterations in clathrin-mediated endocytosis, caveolin-dependent.. View More»
DOI:
10.35248/2155-6156.10001085
