Diabetes, Nutrition and Metabolic Diseases Outpatient Unit, Emergency County Clinical Hospital, Targu Mures, Romania
Mini Review
Patients with Type 1 Diabetes and the Effect of C-Peptide on Diabetic Neuropathy
Author(s): Simona Cernea*
Contrary to what was previously believed, new research demonstrates that proinsulin C-peptide has significant physiological effects and exhibits the traits of a bioactive peptide. Studies in type1 diabetes, both in humans and in animal models, show that replacement amounts of C-peptide can enhance peripheral nerve function and delay or reverse the onset of aberrant nerve anatomical changes. C-peptide replacement improves peripheral nerve function in diabetes type 1 patients with early-stage neuropathy as measured by sensory nerve conduction velocity and quantitative sensory testing. Similar to this, autonomic nerve dysfunction is improved after receiving C peptide for up to three months. The mechanisms of action are related to the capacity of C-peptide to reverse diabetes-induced reductions in endoneurial blood flow, in -ATPase activity, and in the modulation of neurotropic factors. T.. View More»
DOI:
10.35248/2155-6156.1000970
