Journal of Diabetes & Metabolism

ISSN - 2155-6156

Short Communication - (2021) Volume 12, Issue 6

Neuroprotective and Antioxidative Potentials of Aqueous Crude Extract of Sterculia Tragacantha Leaf in Streptozotocin-Induced Diabetes in Rats

Olusola Augustine O1 and Onikanni Sunday Amos1,2,3*
*Correspondence: Onikanni Sunday Amos, Faculty of Science, Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo-State, Nigeria, Tel: + 2348118138703, Email:

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Background: In the western part of Nigeria, different medicinal plants including Sterculia tragacantha has been proved in managing diabetes mellitus with no scientific basis. This research focus on the neuroprotective and antioxidative potential of aqueous crude extract from S. tragacantha leaf (AESTL) using streptozotocin-induced diabetes using albino rat model.

Methodology: AESTL was prepared (w/v) and its effect on biomarkers of inflammation; together with some oxidative stress, markers on the brain of streptozotocin-induced diabetic rats were evaluated.

Results: The results showed that diabetic rats treated with AESTL exhibited an inhibitory effect on the neurotransmitters: acetylcholinesterase (AchE), butyrylcholinesterase (BChE), dopamine, serotonin, NO and Na+K+ ATPase, in a dose dependent manner, on the brain of the animals when compared with diabetic control. Furthermore, the results revealed that no similar effect was observed in the activities of catalase (CAT) and superoxide dismutase (SOD) in the brain of the control and diabetic rats treated with (150 and 300 mg/kg of AESTL). Also, this was observed on metformin (standard drug) group with similar effect with the control group but the vehicle (untreated diabetic group) when compared with the control group and diabetic rats treated with (150 and 300 mg/kg of AESTL) in CAT and SOD showed significant (p < 0.05) increase within the stipulated days of the experiments. In addition, brain content of the glutathione (GSH), glutathione-S-transferase (GST) and glutathione peroxidase (GPx) were significantly increased with co-administration of the AESTL doses when compared with the vehicle.

Conclusion: Inhibitory effect of AChE, BChE and some other biomarkers of inflammation and antioxidative potentials by AESTL could be the major breakthrough in the management of diabetes mellitus.


AESTL; Biomarkers of inflammation; Metformin; Neurotransmitters; Oxidative stress markers; Sterculia tragacantha; Inhibitory effect

Present study, as shown in Figure 5a, revealed that AESTL ameliorates the damage done in all treated group when compared with untreated group. This finding is in agreement with previous study in association with an increase in thiobarbituric acid reactive substances (TBARS) in the tissue. Alteration in any antioxidative defense system induces lipid peroxidation and oxidative stress. Enzymes such as SOD, catalase, glutathione peroxidase, glutathione-s-transferase as well as glutathione form the defense system, which usually protects the cell against oxidative damage. In this research study, most of the oxidative stress markers were significantly decreased in streptozotocin-induced rats as shown in Figures 5b, 6 and 7. This is attributable to the medicinal values in AESTL treatment. It has been established that CAT, SOD and GPx play important roles as protective enzymes against free radical formation in tissues. The present studies validate protective roles of the extract (AESTL) in reducing peroxidation level and restore the damaged levels of antioxidant enzymes system.


It can be concluded from this study that AESTL showed great potentials in ameliorating the diabetic conditions, thereby play a protective role on the brain against diabetogenic-oxidative stress causing change in the levels of peroxidation thereby decreasing activities of oxidative markers. Therefore, in reducing diabetesassociated oxidative stress; AESTL could be very helpful in diabetes mellitus management.


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Author Info

Olusola Augustine O1 and Onikanni Sunday Amos1,2,3*
1Faculty of Science, Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo-State, Nigeria
2Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Ekiti state, Nigeria
3Faculty of Science, Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo-State, Nigeria

Citation: Olusola Augustine O, Sunday Amos O (2021) Physico-chemical and Stabilization Effect of Lemon Grass (Cymbopogon citratus Stapf) Tea for Diabetes Management. J Diabetes Metab. 12:882.

Received: 02-Oct-2020 Published: 30-Mar-2021, DOI: 10.35248/2155-6156.21.12.882

Copyright: © 2021 Olusola Augustine O, et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.