Faculty of Science, Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo-State, Nigeria
Short Communication
Neuroprotective and Antioxidative Potentials of Aqueous Crude Extract of Sterculia Tragacantha Leaf in Streptozotocin-Induced Diabetes in Rats
Author(s): Olusola Augustine O and Onikanni Sunday Amos*
Background: In the western part of Nigeria, different medicinal plants including Sterculia tragacantha has been proved in managing diabetes mellitus with no scientific basis. This research focus on the neuroprotective and antioxidative potential of aqueous crude extract from S. tragacantha leaf (AESTL) using streptozotocin-induced diabetes using albino rat model.
Methodology: AESTL was prepared (w/v) and its effect on biomarkers of inflammation; together with some oxidative stress, markers on the brain of streptozotocin-induced diabetic rats were evaluated.
Results: The results showed that diabetic rats treated with AESTL exhibited an inhibitory effect on the neurotransmitters: acetylcholinesterase (AchE), butyrylcholinesterase (BChE), dopamine, serotonin, NO and Na+K+ ATPase, in a dose dependent manner, on the brain o.. View More»
DOI:
10.35248/2155-6156.21.12.882
