Ihsan Azka Adriansyah and Kuntjoro Harimurti
University of Indonesia, Indonesia
Cipto Mangunkusumo National Central General Hospital, Indonesia
Posters & Accepted Abstracts: J Diabetes Metab
Statement of the Problem: Diabetic nephropathy is one of global health problem
that keep increasing in the recent years. It is one of the common complications
of diabetes mellitus and one of the main cause of chronic kidney disease. Golden
standard for diabetic nephropathy examination is quantification of albuminuria
in 24-hour urine; however, this examin ation is difficult and there are frequent
sampling errors. Several studies show that examination using albumin-tocreatinine
ratio in spot urine sample could be proposed as another method to
diagnose diabetic nephropathy since it is more convenient for the patient. Therefore, the purpose of this study is to find out if
the albumin-to-creatinine ratio in spot urine could be used to diagnose diabetic nephropathy.
Methodology & Theoretical Orientation: A structured internet literature search was conducted using 4 databases, PubMed,
SCOPUS, Cochrane library and Science Direct. Titles and abstracts were screened using predetermined selection criteria and
yield three relevant articles. Selected articles were critically appraised based on its validity, importance and applicability.
Findings: All three journals show that albumin-to-creatinine ratio in spot urine have good sensitivity that is comparable with
quantification of albuminuria in 24-hour urine to diagnose diabetic nephropathy.
Conclusion & Significance: Examination using albumin-to-creatinine in spot urine can be used for screening and diagnosis of
diabetic nephropathy. Recommendations are made for further study to be done in patient in primary health care as a method
to do screening in diabetic patients.
1. McFarlane P, Gilbert R E, MacCallum L, et al. (2013) Canadian Diabetes Association 2013 Clinical practice guidelines for the prevention and management of diabetes in Canada: Chronic Kidney Disease in Diabetes. Can J Diabetes; 37(1): S130-S136.
2. Nah E H, Cho S, Kim S, et al. (2017) Comparison of urine albumin-to-creatinine (ACR) Between ACR Strip test and quantitative test in prediabetes and diabetes. Ann Lab Med.; 37: 28-33.
3. Teimoury A, Iraj B, Heidari-Beni M, et al. (2014) Why 24 hrs. urine albumin excretion rate method still is used for screening of diabetic nephropathy in Isfahan laboratories? International Journal of Preventive Medicine; 5(3): 341-347.
4. Pathania M, Rathaur V K, Yadav N, et al. (2013) Quantitative micro-albuminuria assessment from �??Random voided urinary albumin: Creatinine ratio versus�?? 24 hours urinary albumin concentration�?? for screening of diabetic nephropathy. Journal of Clinical and Diagnostic Research; 7(12): 2828-2831.
5. Lambers Heerspink H J, Brantsma A H, de Zeeuw D, et al. (2008) Albuminuria assessed from first-morning-void urine samples versus 24-hour urine collections as a predictor of cardiovascular morbidity and mortality. Am J Epidemiol; 168: 897-905.
Ihsan Azka Adriansyah is a graduated Doctor from Faculty of Medicine, University of Indonesia. His research interest is in nephrology and urology.