Journal of Diabetes & Metabolism

ISSN - 2155-6156


Antioxidant, anti-lipase and anti-alpha amylase properties of water extracts of Anvillea radiata (Asteraceae)

14th International Conference and Exhibition on Targeting Diabetes and Novel Therapeutics

October 17-18, 2016 Kuala Lumpur, Malaysia

Ould el Hadj-khelil A, Telli A, Toualeb N, Zergat M, Rouidj I, Esnault M A and Ould el Hadj

Université Kasdi Merbah-Ouargla, Algeria
Ghardaïa University, Algeria
University of Rennes1, France

: J Diabetes Metab

Abstract :

Anvillea radiata (Asteraceae) is an endemic species of North Africa which is used in folkloric medicine for treating hypertension, gastro-intestinal ailments, genital diseases and diabetes mellitus. The aim of the present study was to evaluate some biological activities of water extracts of Anvillea radiata areal part. The water extracts of Anvillea radiata areal part were obtained in the same conditions like the traditional preparation modes (decoction and infusion). The antioxidant potential of water extracts was measured by three different assays: ferric reducing antioxidant power (FRAP) and scavenging activity on 2, 2'-azino-bis (3-ethylbenzothiazoline- 6-sulphonic acid) (ABTS?+) radical cation and on 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical. Moreover, lipase and alpha amylase inhibition assays of water extracts of Anvillea radiata were also evaluated. The contents of total phenolic (28.79±2.16 mg GAE/g of dry weight), flavonoids (16.37±1.45 mg RE/g DW) and condensed tannins (8.02±0.72 mg CE/g DW) were found significantly higher in decoction than in infusion. The IC50 values based on the FRAP (21.39±1.08 μg/ml), ABTS (73.92±6.47 μg/ml) and DPPH (14.90±0.38 μg/ml) were lower in comparison with standard antioxidants (butylated hydroxytoluene, trolox) showing potential antioxidant properties. Lipase and alpha amylase inhibition assays proved that the inhibition rate of decoction varied respectively from 78.95% and 81.54% to 29.33% and 31.76% from the highest (8 mg/ml) to the lowest concentration (0.5μg/ml). In conclusion, the present results revealed that Anvillea radiata has hypoglycemic and anti-obesity properties.

Biography :

Ould el Hadj-khelil A has completed his PhD from Rennes 1 University. Currently, she is a Professor of Biology and Research Director in the Department of Biology at Kasdi Merbah University of Ouargla. She is the Chair of Scientific Council in Natural and Life Sciences Faculty of Ouargla University. She is the Algerian responsible of PHC Tassili project code 11DMU 822. She participates in many scientific manifestations as member and as chair. She has more than 29 communications. She has published more than 18 papers in national and international journals.

Email: [email protected]