Soha M Abd El Dayem, Ahmed A battah and Abo El Magd El Bohy
National Research Centre, Egypt
Cairo University, Egypt
Posters & Accepted Abstracts: J Diabetes Metab
Objective: We are aiming to evaluate apelin and nitric oxide (NO) in type 1 diabetic patients and its relation to vascular affection. Patients & Methods: The study included 62 type 1 diabetic patients and 30 healthy volunteers of the same age and sex. Blood samples were taken for assessment of apelin, NO, glycosylated hemoglobin, and lipid profile. Urine samples were taken for assessment of albumin/creatinine ratio. Flow mediated dilatation (FMD) via ultrasound was done. Results: The study included 62 patients with type 1 diabetes, their mean age were 16.3±1.5 yrs (14.0�??19.0 yrs), and mean duration of diabetes were 9.4±2.9 yrs (5.0�??16.5 yrs). FMD and FMD/ nitrate mediated dilatation (NMD) ratio were significantly lower in diabetics. Nitric oxide was significantly lower, while apelin and albumin/ creatinine ratio were significantly higher than controls. No significant correlation was found between apelin, NO, FMD, albumin/creatinine ratio or BMI. Conclusion: Diabetic patients had endothelial dysfunction and elevation of apelin, but they does not related to each other. BMI had no relation to apelin which indicate that obesity had no role to apelin. Further large study is recommended to detect the relationship of apelin with vascular affection by assessing large number of diabetics with and without complication.
Email: ahmedbattah40@yahoo.com
