D S Mohale and A V Chandewar
P. Wadhwani College of Pharmacy, India
Posters & Accepted Abstracts: J Diabetes Metab
Present study was undertaken to evaluate the effect of tubers of Amorphophallus paeoniifoliusin the treatment of diabetic neuropathy. Amorphophallus paeoniifolius (Araceae family) have been widely used as a potential natural medicinal product in traditional Indian Ayurveda. Animals were divided in 4 groups (n=6), diabetes was induced by STZ 60 mg/kg, IP and treated with methanolic extract of Amorphophallus paeoniifolius at of 250 mg/kg and 500 mg/kg p.o. dose for 3 weeks. Measurement of blood glucose level was used to determine diabetes. For determination of diabetic neuropathy tail flick, swim endurance test and Rota-road method were used. There was significant increase (p<0.01) in the blood glucose level in negative group compared to control group of rats. There was decrease (p<0.01) blood glucose level in STZ+AP extract (250 mg/kg) and STZ+AP extract (500 mg/kg) treated group compared to Negative-control Group. There was significant increase (p<0.01) in time to flick the tail of diabetic rats compared to control group which were significantly improved in STZ+AP extract (250 mg/ kg) and STZ+AP extract (500 mg/kg) treated group compared to Negative-control group. Muscle strength was significantly decreased (p<0.01) in rats treated with STZ analyzed on Rota-rod apparatus. There was significant improvement (p<0.01) in muscle strength in STZ+AP extract (250 mg/kg) and STZ+AP extract (500 mg/kg) treated group compared to negative-control group. Mobility time was decreased in negative group measured in force swim test and treatment with STZ+AP extract (250 mg/kg) and STZ+AP extract (500 mg/kg) shows significant improvement in mobility time treated group compared to negativecontrol group. Present study concludes that methanolic extract of Amorphophallus paeoniifolius may be useful in treatment and management of diabetic neuropathy.