Rabab Mohamed1, Mohamed M Radwan2, Guoyi Ma2, Mena M Thabet3, Mohamed A Seliem4, Tarek A Mohamed5 and Mahmoud El Sohly2
1Beni Suef University, Egypt 2University of Mississippi, USA 3Misr University for Science and Technology, Egypt 4Cairo University, Egypt 5National Institute of Oceanography and Fisheries, Egypt
Posters-Accepted Abstracts: Nat Prod Chem Res
Ten compounds including five sterols (1-5), three sesquiterpenes (6-8) and two fatty acid esters (9-10) have been isolated from the Red Sea soft coral Sinularia terspilli. The anti-leukemic, anti-leishmanial, antimicrobial, and antimalarial activities of the isolated compounds and some acetylated derivatives (1Ac, 3Ac, 4Ac, 5Ac) were evaluated. Compounds 4, 5, and 5Ac exhibited strong cytotoxic activity against human leukemia cell lines HL60 and K562 with IC50 values of 4.0, 2.0 and 25 nM, respectively for HL60 and 5.0, 3.0 and 40 nM for K562.
Email: rmwork06@yahoo.com
