Md Ashwaq Hussain, K Shanker and Rama Mohan Gupta V
Pulla Reddy Institute of Pharmacy, India
Jawaharlal Nehru Technological University, India
Nanoparticles emerge as potential pharmacological carriers that can be applied in the regenerative medicine, diagnosis and drug delivery. Many chemical and physical procedures used for synthesis of metallic nanoparticles are fought with major problems like toxic solvents, hazardous by-products and high energy consumption. To overcome the problems, plants, algae, fungi, bacteria, and viruses have been used for production of low cost, energy efficient and nontoxic metallic nanoparticles. In the current study, the synthesis of silver nanoparticles was accomplished using Momordica charantia ethanolic extract. The synthesized nanoparticles were characterized by UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (Fe-SEM) and X-ray diffraction (XRD). Highly crystalline, roughly spherical and cuboidal silver nanoparticles of 30-70 nm in size were synthesized and itâ??s IC50 values and LD50 studies (as per OECD guidelines number 423) of 82.39±3.1 μg/ml and 2000 mg/kg respectively. Biologically synthesized silver nanoparticles exhibited strong hepatoprotective effect against Hep-G2 cell lines. The approach of green synthesis seems to be cost efficient, eco-friendly and easy alternative to conventional methods of silver nanoparticles synthesis.
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