Naeti Suksomboon
Mahidol University, Thailand
Posters & Accepted Abstracts: J Diabetes Metab
Objective: To compare the efficacy and safety of glyburide with metformin in treating gestational diabetes mellitus. Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that compared efficacy and safety of glyburide with metformin in gestational diabetes mellitus (GDM) patients. We used electronic databases to conduct the literature search for study identification along with a hand search of pertinent journals and conference proceedings. Results: 3 studies involving 421 patients met inclusion criteria for our review. A significant increase in the risk for large for gestational age (LGA) babies (RR 2.32; 95%, CI 1.23-4.37, p-value=0.009) was observed in glyburide group compared to metformin, whereas a non-significant increase in the risk for macrosomia (RR 2.05; 95%, CI 0.67-6.27) and neonatal hypoglycemia (RR 1.09; 95%, CI 0.61-1.97) was noticed. Results remained non-significant for preterm births and caesarean section. On the other hand, a significant decrease in fasting glucose levels (MD, -2.67 mg/dl; 95%, CI -5.19, -0.16; p-value=0.04) was noticed with glyburide, while difference was non-significant for postprandial glucose levels. Conclusion: Treating GDM with glyburide is likely to increase risk for LGA births.
Email: naeti.suk@mahidol.ac.th
