Ciddi Veeresham, Noaf Khalid and Uma Mahesh Balekeri
Kakatiya Univeristy, India
Posters-Accepted Abstracts: Nat Prod Chem Res
Practice of using herbal remedies as a strategy against aging skin has been evolved as an imperative step to accomplish comprehensive skin rejuvenation. Present study is aimed to prepare and evaluate a poly herbal cream containing standardized extracts of Aloe vera (A), Ocimum sanctum (O) and Punica granatum peel (P) at different ratios. Santalum album, Citrus aurantium, Olea europa, Prunus amygdalus oils, cetyl alcohol and stearic acid were used in a ratio of 0.1:0.1:1.0:0.5:0.5 and 3.0, respectively, along with preservatives to formulate a cream base for formulation water in oil (W/O) creams, i.e., F1 to F6. Prepared formulations were evaluated for formulation parameters like pH, viscosity, spreadabilty, extrudability and stability. Further, formulations were also evaluated for anti-oxidant, anti-microbial and Advanced Glycation End Product Inhibition (AGE) properties. Formulations F3- F6 have shown no phase separation upon storage. Formulations F3 and F6 have featured lower spreadability and extrudabiltiy. The order of anti-oxidant ability of the all formulations found as F6>F5>F4>F3>F2>F1. Formulations F4 and F5 shown comparable AGE inhibitory and anti-microbial effects to standards aminoguanidine and neomycin sulphate cream, respectively. However, F4 showed higher AGE inhibitory effect vis-a-vis with F5. In human volunteer�??s study, the formulations F4 and F5 shows no redness, edema, inflammation and irritation during irritancy studies. The synergistic effects of formulation F4 containing A:O:P (each 1.6% w/w) has addressed hyperpigmentation, erythema, wrinkles and firmness of skin more significantly than F5. These finding indicate the significant anti-aging potential of examined poly herbal anti-aging cream.
Email: ciddiveeresham@yahoo.co.in
