Khoshvaghti Amir, Eslami Reza, Momenzade Mahmud, Ebadi Ahmad and Nezami Asl Amir
AJA University of Medical Sciences, Iran
Introduction: Diabetes prevalence is increasing. This metabolic disorder is a spectrum from relative to complete insulin deficiency. Skin structures are changed by diabetes in many ways. Comparing with normal population, prevalence of skin infections are increased in diabetics. General appearance (face and facial skin in special) contribute to quality of life. Some believe that diabeticsā?? appearances are older than usual. Aim: Aim of this study is to find out the relation between diabetes and skin aging. Material & Method: PubMed articles have been reviewed for finding the answer. Results: Process of non-enzymatic glycation takes place naturally within aging. Observations showed that non-enzymatic glycation increased severely in diabetes, leading to formation of advanced glycation end products which are strongly related to micro vasculopathy. Diabetes will result in: Functional micro angiopathy due to advanced glycation end production; addition of peripheral neuropathy; physicochemical characteristics changes of the fibrous collagen and; yellowish hue of skin and nails. Skin glycation causes similar changes to aging and photoaging. Reactive oxygen species are also produced. General appearance and face in special contribute to quality of life. The rational is application of a topical product (antioxidants or an anti-glycation plus antioxidant) in addition to a sunscreen cream..
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