El-Attar H A and Gaber E W
University of Alexandria, Egypt
Introduction: Type 2 diabetes cause diabetic nephropathy which is a common cause of end stage renal disease. Dopamine is involved in the regulation of blood pressure. Renalase metabolizes circulating catecholamines and regulates blood pressure. Aim: Assessing the relationship between Dopamine and Renalase in type 2 diabetic patients with and without diabetic nephropathy. Subjects & Methods: This study was conducted on 80 subjects. Group 1:10 healthy volunteers as controls, group 2:60 type 2 diabetic patients with normal or increased albumin excretion rate (AER) and group 3:10 type 2 diabetic patients on maintenance hemodialysis (HD). To all studied subjects thorough clinical assessment and laboratory investigations included: Estimation of serum levels of fasting glucose (FSG), urea, creatinine, calcium and phosphorus. Estimation of urinary albumin/creatinine ratio (ACR) to assess AER and estimation of plasma Dopamine and serum Renalase were done by ELISA. Results: There were no significant differences in the mean Dopamine levels between the three studied groups. Renalase level was significantly higher in HD patients compared to controls and other diabetic patients. Diabetic patients with increased AER had significantly higher systolic blood pressure, serum creatinine and Renalase levels. Diabetic patients with increased serum creatinine â?¥1.5 mg/dl had significantly higher systolic and diastolic blood pressures. They also had significantly higher AER, FSG, Dopamine and Renalase levels. ACR was positively correlated with duration of diabetes, systolic and diastolic blood pressure and serum creatinine. Renalase was positively correlated with diastolic blood pressure, ACR, serum creatinine, phosphorus and Dopamine Conclusion: Serum levels of Renalase are increased in type 2 diabetic patients with renal dysfunction. Renalase levels may be increased to compensate the increase in Dopamine level. The higher Renalase level in HD patients may be due to much lower Renalase clearance, higher production or slower degradation in these patients.
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