Journal of Diabetes & Metabolism

ISSN - 2155-6156


Effect of Lawsonia inermis Linnaeus leaf extracts on blood glucose level in normal and streptozotocininduced diabetic rats

14th International Conference and Exhibition on Targeting Diabetes and Novel Therapeutics

October 17-18, 2016 Kuala Lumpur, Malaysia

Widyawati T, Pane Y S, Hasibuan S S and Satria D

University of Sumatera Utara, Indonesia

: J Diabetes Metab

Abstract :

Lawsonia inermis Linnaeus is one of the plants commonly used in Indonesian community for the treatment of different diseases. The anti-diabetic activity was evaluated by determining whether the extracts lowered the blood glucose level BGL0 of normal rats (hypoglycemic test) or lowered BGL of streptozotocin-induced diabetic rats (SDR). Dried powdered L. inermis leaves were extracted serially with n-hexane (HE), ethylacetate (EAE), ethanol (EE), water1(WE1) and water2 (WE2). Hypoglycemic in normal rats showed only HE significantly reduce fasting BGL at 3 h observation. However, in antihyperglycemic test in SDR, single-dose administration of the extracts showed that only EAE reduced BGL signficantly at 3 h observation. The present work conclude that EAE is the most active extract as antihyperglycemic.

Biography :

Widyawati T is a Lecturer at Medical Faculty, University of Sumatera Utara since 2003. Currently, she is pursuing her PhD at Pharmaceutical Sciences University Sains Malaysia and has submitted her final thesis.

Email: [email protected]