Journal of Diabetes & Metabolism

ISSN - 2155-6156

Effects of chronic moderate intensity exercise on blood glucose, fasting insulin, FFA and insulin resistance in male Wistar rats with diabetes mellitus

Joint Eveny on 2nd Annual Congress on Diabetes and its Complications & 8th Annual Congress on Probiotics, Functional Foods & Nutraceuticals

March 25-26, 2019 Hong Kong

Aywar Zamri, Achmad Rudijanto and Putu Moda Arsana

RSUD Dr. Saiful Anwar, Indonesia

: J Diabetes Metab

Abstract :

Aim: The aim is to assess whether chronic moderate intensity exercise had effects on blood glucose, fasting insulin, FFA and insulin resistance in male Diabetes Mellitus (DM) Wistar rats.

Method: A 10 weeks experimental laboratorial study with Wistar diabetes Rattus norvegicus strain rats using pretest-posttest comparison group design. Twenty (20) rats were divided into four groups of rats, five rats per group. The four groups were: Normal rats with sedentary lifestyle, normal rats with exercise, DM rats with sedentary lifestyle and DM rats with exercise. In the exercise groups (normal and DM), rats performed a treadmill for 10 weeks whereas speed and duration were gradually increased every two weeks, starting at 10 m/minute for 10 minutes and increased until 26 m/minute for one hour a week 9 and 10. Blood plasma examination was performed in each group for fasting blood glucose, fasting insulin, FFA and HOMA-IR was calculated at baseline and the end of week 10.

Results: There were no significant differences between before and after exercise in the group of normal exercise rats and DM exercise rats but there was a tendency of decreasing plasma glucose (pre 143.59; post 121.65, p 0.39), insulin (pre 16.56; post 15.38, p 0.32), FFA (pre 19.93; post 14.05, p 0.36) and HOMA-IR (pre 5.87; posts 4.62, p 0.27) in normal rats before and after exercise. Likewise, there was a downward trend in DM rats exercise blood glucose levels (pre 242.26; Post 222.03, p 0.63), insulin (pre 26.5; post 24.45, p 0.12, HOMA-IR (pre 15.58; post 13.5, p 0.37) and FFA (pre 26.5; post 24.45, p 0.12) before and after exercise.

Conclusion: There was a decrease in insulin resistance as indicated by a tendency to decrease HOMA-IR, fasting insulin, plasma glucose, plasma FFA. It might require longer than 10 weeks of exercise to see a significant decrease on these parameters.

Biography :