Surgery: Current Research

ISSN - 2161-1076

Histopathological changes in rabbit gastric mucosa due to chronic exposure to pickled vegetables

13th International Conference on Surgical Pathology & Practice

March 27-28, 2017 Madrid, Spain

Amirreza Dehghanian

Shiraz University of Medical Sciences, Iran

Posters & Accepted Abstracts: Surgery Curr Res

Abstract :

Gastric cancer is very common in Iran. Daily consumption of pickled vegetables is a routine dietary habit in most areas of Iran. Having considered the possible effect of pickled vegetables on gastric mucosa it can be of importance to study the relationship between the two. We have studied the histo-morphological effects of pickled vegetables on the rabbit gastric mucosa. 40 and 20 healthy male rabbits were respectively allocated in the experimental and control groups. The rabbits were fed freely with pickled (experimental group) and fresh vegetables (control group) for one year. Gastric mucosa of the rabbits was examined and the results were compared. In addition to all the rabbits of the control group, 14 rabbits (35%) of the experimental group had normal gastric mucosa. The rest showed abnormal changes including atypia -so called indefinite for dysplasia- in 10 (25%), low grade dysplasia in 14 (35%) and high grade dysplasia in 2 (5%). The analysis showed significant difference between results of the two groups (P<0.001). Daily consumption of pickled vegetables can produce atypical and dysplastic changes in gastric mucosa. Such pre-neoplastic changes can potentially transform to gastric carcinoma. This process could be prevented by reduction or cessation of daily pickled food consumption.

Biography :

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