Surgery: Current Research

ISSN - 2161-1076

In-office preoperative sonographic axillary staging streamlines selection of patients for neoadjuvant therapy

13th International Conference on Surgical Pathology & Practice

March 27-28, 2017 Madrid, Spain

Rodolfo Arcovedo

Sharp Healthcare, San Diego, USA

Scientific Tracks Abstracts: Surgery Curr Res

Abstract :

Background/Objective: Determining nodal status is paramount in the medical management of breast cancer. Preoperative identification of axillary involvement derives the following benefits: improved prognostic information, earlier neoadjuvant therapy, increased opportunities for breast conservation, and a pathological complete response to chemo, in a subset of patients. Despite this, many studies provide contradictory evidence of the efficacy of the utilization of diagnostic techniques in the assessment of axillary involvement. We assessed the clinical value of in-office preoperative sonographic axillary nodal staging using ultrasound (US) with/ without nodal tissue sampling (NS) in patients with primary breast cancer to assist in selecting patients for neoadjuvant therapy. Methods: 165 single-practice patients with primary breast cancer that underwent an in-office axillary US+/-NS by the surgeon were retrospectively analyzed and reviewed. Sensitivity and specificity of US+/-NS diagnosis of nodal involvement in these patients were compared against final pathological results of intraoperative Sentinel Node Biopsy (SLNBx) and/or Axillary Dissection (AxD). Subgroups by histopathological features, age, tumor size, and BMI were created and analyzed in their potential impact on sensitivity, specificity, positive predictive value, and negative predictive value of axillary nodal involvement. Data was statistically analyzed using Studentā??s two-tailed t-test Graph pad software. Result: By using US+/-NS preoperatively, the axillary nodal status of 27 patients (TP+FP) tested positive and 138 patients (TN+FN) tested negative. The sensitivity (56.8%) and specificity (98.4%) of axillary nodal status using US+/-NS preoperatively was compared to the gold standard (SLNBx/AxD) postoperative (>90% sensitive and specific). By utilizing US+/-NS, 39 patients were determined to have an increase in the cancer staging (larger tumor size or nodal status), and 19 patients (TP) avoided SLNBx (streamlined to AxD). Ten patients that avoided SLNBx were HER2+ or triple negative. US+/-AS was more sensitive in the following groups: Age <50 years and tumors that were T2 (P<0.085). Conclusion: In staging breast cancer, a key element is assessing axillary nodal involvement. US+/-NS is a great tool to assist in preoperative staging. Our albeit underpowered, study showed that the utilization of US+/-NS had the greatest sensitivity in younger patients with tumor sizes T2 or greater. The performance of this simple in-office ultrasound axillary staging allowed us to capture 11.5% more patients who were good candidates for neoadjuvant chemotherapy. Half of these patients had tumor characteristics with potential for a complete pathologic response to chemotherapy. By finding the node positive patients preoperatively, one can direct more patients to neoadjuvant chemotherapy, select those requiring axillary dissection and plan delayed reconstruction should they need post-mastectomy radiation. Also, patients selected for axillary dissection avoided sentinel lymph node procedure. This reduced the financial and clerical burden and patient apprehension.

Biography :

Rodolfo Arcovedo was awarded with a PhD from Universidad La Salle, Facultad Mexicana de Medicina, México City in the year 1991. He holds a Post-graduate training as Transitional Resident at Chestnut Hill Hospital, Philadelphia in 1993 followed by University of Illinois Metro Group Hospitals program in General Surgery from July 1993 until July 1999, Chicago. Currently, he is working as an Assistant Clinical Instructor at LECOM Medical School since 2014. His international experience includes various programs, contributions and participation in different countries for diverse fields of study. He has wide range of publications in various national and international journals. He serves as a member of various societies.

Email: [email protected]