Foundation Institute San Raffaele G. Lily, Italy
Posters-Accepted Abstracts: J Steroids Hormon Sci
Context: Many papers demonstrated the inositol effects in terms of better insulin sensitivity, ovulatory function, androgen levels reductions, FSH ovarian response and on the metabolic pattern. Objective: To evaluate the therapeutic effect of the insulin �?? sensitizing integration on the androgenetic alopecia (AA). Methods: Exclusion Criteria: use of hormonal medications including oral contraceptives or insulin-sensitizing in the previous six months. Inclusion Criteria: Hyperandrogenism with skin symptoms. AA rated according to Ludwig scale, hirsutism rated with F.G. score modified (Hatch), acne based on the face, chest and back injuries number. Patients: Longitudinal observational study on 10 - 30pts. Interventions: BMI > 25: MYO 550 mg + DCI 13.8 mg (ratio 40/1) plus folic acid 200 mg, soft gel caps twice daily. BMI < 25: MYO 2gr plus folic acid 200 mg, soluble powder twice daily. Plasma levels, clinical signs and self- patients�?? assessment were recorded at three and six months of treatment. Main Outcome Measures: 20-70% hair loss reduction without side effects. Results: Significant reduction in BMI/HC, PCOS and cutaneous hyperandrogenism signs almost all in resolution. Conclusions: Previously our results support the hypothesis about inositol as second FSH messenger. The treatment demonstrated an androgen and their peripheral effects reduction. Further possible double - blind randomized studies need to better understand the pilosebaceous unit action mechanism to validate the inositol administration definitively.
Giuseppe Gullo is a PhD student Fondazione Istituto San Raffaele G. Giglio di Cefalù. He has published several articles in reputed journals.