Journal of Diabetes & Metabolism

ISSN - 2155-6156

Metabolomic profiling, antioxidant capacity and in vitro anticancer activity of some compositae plants growing in Saudi Arabia

11th Asia Pacific Diabetes Conference and Expo

July 11-12, 2016 Brisbane, Australia

Mousa O Germoush, Sabry A El-Naggar, Ibrahim B Abdel-Farid and Hassan A Elgebaly

Aljouf University, KSA
Tanta University, Egypt
Aswan University, Egypt

Posters & Accepted Abstracts: J Diabetes Metab

Abstract :

The present study was conducted to evaluate the metabolic profiling, antioxidant capacity and anticancer activities of some common widely grown plants of the family Compositae. The total phenolics, flavonoids, anthocyanins, saponins, total antioxidant capacity (TAC) and 2,2-diphenyl1picrylhydrazyl (DPPH) assays were determined in the selected plant extracts. In vitro anticancer activity was also assessed using human hepatocellular carcinoma (HepG-2) and breast adenocarcinoma (MCF-7) cell lines. The plant species revealed different metabolomic profiling. Artemisia showed the highest contents of the detected secondary metabolites compared to other plant extracts. Pulcaria crispa showed the highest inhibition concentration 50% (IC50) among the screened extracts against HepG-2 (8.9 μg/ml) and MCF-7 (8.14 μg/ml). The high performance liquid chromatography analysis (HPLC) of P. crispa extract revealed the presence of high content of three phenolic compounds, benzoic, chlorogenic acid and vanillic acid, along with two polyphenolic compounds, hesperidin and quercetrin. In summary, among the screened extracts, P. crispa has the most potent anti-tumor activity in vitro against HepG-2 and MCF-7 cell lines.

Biography :

Email: germoush@hotmail.com

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