Lingala Suresh, P Sagar Vijay Kumar and G V P Chandramouli
National Institute of Technology, India
Posters-Accepted Abstracts: Nat Prod Chem Res
A simple and facile synthesis of a series of novel pyrano[2,3-d]pyrimidines have been achieved successfully via one-pot threecomponent reaction of 2-amino-7-methyl-5-oxo-4-phenyl-4,5-dihydropyrano[4,3-b]pyran-3-carbonitriles, DMF-DMA and aryl amines in the presence of 1-butyl-3-methyl hydrogensulphate [Bmim] HSO4 ionic liquid. This method has several advantages of producing high yields, clean reaction, simple methodology and short reaction times. The synthesized compounds were evaluated for their antimicrobial activity against gram-positive, gram-negative and different Candida strains. Among the screened derivatives, the compounds pyrano[2,3-d]pyrimidines were found to be active against both bacterial and Candida strains with MIC values ranging between 3.9 to 31.2 μg.mL-1. In addition, the compound pyrano[2,3-d]pyrimidines showed good minimum bactericidal concentration, minimum fungicidal concentration and anti-biofilm activities. Furthermore, the mode of antifungal action for the promising compound pyrano[2,3-d]pyrimidines were evaluated in C. albicans MTCC 1637 through the ergosterol biosynthesis inhibition process.
Lingala Suresh is currently pursuing his PhD under the supervision of Professor G V P Chandramouli at National Institute of Technology, Warangal. He is working as a Research Scholar in Department of Chemistry. He has 2 publications in reputed journals.
Email: lsureshnitw@gmail.com
