Faha Kalim Siddiqui, Syed Aun Haider Rizvi, Bushra Humayyun and Saima Mahmood Malhi
Dow University of Health Sciences, Pakistan
Posters-Accepted Abstracts: J Diabetes Metab
A principle biguanide isolated from Galega officinalis, metformin was discovered as an anti-hyperglycemic agent in 1923. Being the potential anti-diabetic drug, its widespread use has led to its inclusion in the World Health Organisation Model List of Essential Medicines. Apart from type II diabetes, metformin is the drug of choice in polycystic ovarian syndrome (PCOS) in females, although not yet licensed, due to its role in insulin sensitization, circulating androgen suppression and ovulation induction. However, the mechanism of activity of metformin in adult males affecting their reproductive system is still unclear. Literature survey shows the controversial effects on sperm physiognomies and semen characteristics affecting the life span of males as well. In present study, we plan to investigate the effect of orally administered metformin on the reproductive system of adult male rodents. Healthy adult male animals will be divided in four groups. One group will serve as control and other three groups will be given three different doses of metformin. Testicular weight, sperm count, sperm motility and testosterone levels at day 1, 3, 7 and 14 will be assessed and compared in all animals. With increasing infertility cases in adult diabetic males, it is high time a robust clinical study clarifies the role of metformin in altering the male reproductive system. This experimental study will provide basis to get a clear picture of the impact of metformin on male reproductive system and may result in a breakthrough in male infertility management.
Email: smmhej@gmail.com
