Patrizio Tatti
NHS, UK
Posters-Accepted Abstracts: J Diabetes Metab
Many studies in the recent decades proved the existence of an impact of Obstructive Sleep Apnea (OSA) and Sleep disturbances on alterations of glucose metabolism. This phenomenon is evident in Diabetes. Most of the available data evaluated an effect on HbA1c, which in itself is the composite of many different variables, like Fasting blood glucose, Postprandial glucose, Glucose Peaks, Glucose Oxidation, Neoglucogenesis, Insulin Mediated glucose Oxidation, Non-Insulin Mediated Glucose oxidation, and many other less well known components. Among this constellation Glucose Variability seems to be very relevant to the cardiovascular damage of Diabetes. On the other hand OSAS and Sleep disturbances tend to occur together very frequently in the diabetic population and it is difficult to single out their respective roles on the altered glucose variability. We studied the impact of OSAS and Sleep Disturbances on Blood glucose variability, both in the fasting state than on the 7-day glucose variability as recorded with the Continuous Subcutaneous Glucose monitoring. According to these observational studies sleep disturbances are the cause of minor degrees of increased glucose variability, irrespective of the causes. If serious OSA supervenes the variability is greatly exaggerated. Both conditions should be treated, but the presence of severe OSAS is a dangerous condition that should be treated promptly.
Email: info@patriziotatti.it
