Biological Systems: Open Access

ISSN - 2329-6577


Predicting new molecular targets of ABPA using network pharmacology

3rd International Conference on Integrative Biology

August 04-06, 2015 Valencia, Spain

Vandana Das and Mohana Priya

Posters-Accepted Abstracts: Biol Syst Open Access

Abstract :

Aspergillus fumigatus is the commonest mould causing infection worldwide. It is a ubiquitous fungus found in high concentrations in human homes, in farm environments and compost facilities. Aspergillus fumigatus has a most remarkable, probably unique, place amongst infectious agents in causing life threatening infection in those with damaged immune systems (invasive aspergillosis), disease in those with normal immunity with or without local tissue damage and hypersensitivity diseases (allergic broncho pulmonary aspergillosis, allergic fungal sinusitis). Allergic Broncho Pulmonary Aspergillosis (ABPA) is an immunologic pulmonary disorder caused by hypersensitivity to Aspergillus fumigatus. The population prevalence of ABPA is not clearly known but the prevalence in asthma clinics is reported to be around 13%. The project focuses on novel target/ enzyme identification by Network Based approaches and computational screening of anti-fungal compounds from the herbal plants. The target was identified using Network Analysis which is a Systems Biology approach to understand protein-protein interactions occurring in crucial pathways such as metabolic and signaling pathways. The study gave an insight into developing a lead compound from the extracts of herbal plant of Adhatota vasica, compounds such as Trihydroxycycloart-24-en-26-oicacid and Pregnane-3 [4-methyl-3-oxo (1-oxa-4-aza)] has good docking score and minimum glide energy (stable complex), thus it can be considered as potential hits and can be selected for further studies as a lead compound for potential anti-resistant drug for ABPA infection.