Journal of Diabetes & Metabolism

ISSN - 2155-6156

Protein Prenylation in glucose-induced insulin secretion

3rd World Congress on Diabetes & Metabolism

September 24-26, 2012 Marriott Convention Center, Hyderabad, India

Anjan Kowluru

Keynote: J Diabetes Metab

Abstract :

Insulin secretion from the pancreatic beta-cell is regulated principally by the ambient concentration of glucose. However, the molecular and cellular mechanisms underlying the stimulus-secretion coupling of glucose-stimulated insulin secretion [GSIS] remain only partially understood. Emerging evidence from multiple laboratories suggests key regulatory roles for GTP-binding proteins [G-proteins] in the cascade of events leading to GSIS. This class of signaling proteins undergoes a series of requisite post-translational lipidation [e.g., prenylation] by a group of enzymes referred as prenyltransferases.

Biography :

Anjan Kowluru is Associate Dean and Professor Pharmaceutical Sciences and Medicine at Wayne State University. He also holds Senior Research Career Scientist position at the John D. Dingell VA Medical Center in Detroit. Dr. Kowluru is involved in understanding regulatory roles of small G-proteins in islet function in health and diabetes. He published more than 125 papers and presented 225 papers at various local, regional, national and international meetings. His research is supported by grants from the NIH, the Department of VA and other private foundations including the ADA and the JDRF. He serves [or served] on scientific advisory panels at the NIH, the VA, the ADA and the JDRF. He is currently serving [or served] on the editorial boards of several journals, including Endocrinology, Biochemical Pharmacology, American J. Physiology-Endocrinology and Metabolism, Experimental Diabetes Research and the Journal of Diabetes and Metabolism.