Camille K Hunt* , Charlotte E. L. Woodbridge *, Puja Thadani, Thomas M. Barber, Harpal S. Randeva
Warwick Medical School, University of Warwick, UK
Scientific Tracks Abstracts: J Steroid Horm Sci
Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder of great importance due to its prevalence and impact within the female population. Studies that involve women residing in the UK and compare biochemical, anthropometric, and direct/indirect quality of life data between the PCOS phenotypes in a clinical setting are lacking. Methods: This retrospective, cross-sectional study included 142 women with PCOS attending a UK clinic in 2019. The women were diagnosed and classified via the Rotterdam criteria into four phenotypes: A (nâ??=â??74), B (nâ??=â??36), C (nâ??=â??17), and D (nâ??=â??15). The phenotypes were compared using routinely collected data. Significantly, the biochemical measurements were collected during follicular phase to reduce temporal confounds. Findings: â?¢ Frequency: group A=52.11%, B=25.35%, C=11.97%, D=10.56%. â?¢ Anthropometric â?? Weight, BMI, body mass and fat mass were lower in phenotype D (Weight= 77.27kg ± 18.762kg; BMI= 28.47kg/m2 ± 6.830kg/m2; body mass= 73.90kg ± 7.743kg; fat mass= 26.39kg ± 8.397kg) compared to A and B. â?¢ Biochemical Phenotype A showed higher T (compared to D), lower SHBG (compared to group C & D) and higher FAI (compared to C &D), with values of T= 1.99nmol/L ± 0.720nmol/L; SHBG= 32.45nmol/L ± 20.074nmol/L; FAI= 7.57 ± 4.083. HDL was lower in Phenotype A (1.14mmol/L ± 0.289mmol/L) compared to group B, C & D and TG was higher in phenotype A (1.57 mmol/L ± .925 mmol/L) compared to group D. â?¢ QoL Phenotype D had the lowest mFG score (2.38 ± 1.850) but scored highest on the PCOSQ-50 (Hirsutism) (495.45 ± 113.368). Conclusions: Most of the results mirrored previous findings, with some novel aspects. Unfortunately, most QoL data lacked power due to missing data â?? further studies incorporating QoL data with larger sample sizes are needed. Limitations of the study, such as lack of control group, should be rectified in future investigations.
Camille Hunt, a medical student at the University of Warwick. She has extensive research experience in neurological and neuropsychiatric conditions through coordinating clinical trials at the University of British Columbia and involvement with conducting laboratory and clinical research at Kings College London. Recently, she has been focusing on PCOS, completing projects in both primary and secondary clinical settings. Charlotte Woodbridge is a medical student at the University of Warwick with a keen interest in womenâ??s health. She recently won Top Five Poster Prize at the 2024 RCGP (Midland) Education, Research and Innovation Symposium for her poster on managing gestational diabetes in a primary care setting. She aims to continue contributing to the field through her research and clinical practice.
