Aditya Vedula and V Padma
Sree Balaji Medical College and Hospital, India
Scientific Tracks Abstracts: J Diabetes Metab
Peripheral Vascular Disease (PVD) is a major complication and cause of
morbidity in diabetic patients worldwide. Earlier detection of PVD could
prove beneficial to the patients at risk. This is a prospective study done to find out
whether inflammatory markers like hsCRP, Apo-A, Apo-B, homocysteine help in
detecting peripheral vascular disease early. Diabetic patients for more than 3 years
without other comorbid illness were included in the study. After getting the ethical
committee�??s approval, the selected subjects, were tested for hsCRP, Apo-A, Apo-B
and homocystiene levels and doppler study of lower limb vessels were done. Of
the 100 patients, only 25 patients had elevated levels of Apo-A (25%). Apo-B levels
were elevated in 67 patients (67%). Highly sensitive CRP was elevated in 63 patients
(63%). The mean age of the study population was 52 years and the mean duration of diabetes was 8 years. 15% of diabetic
patients had normal HbA1C and did not have elevated biomarker levels. Patients were followed up for 2 years. Of patients
who had elevated biomarkers, 30% developed PVD. This study shows that inflammatory markers like hsCRP, apo-A and apo-B
are sensitive markers for early detection of peripher al vascular disease and thereby for reducing morbidity. Tight control of
diabetes is quintessential to prevent occurrence of complications of diabetes.
References
1. Criqui M H (2001) Peripheral arterial disease - Epidemiological aspects. Vasc. Med.; 6: 3-7.
2. Muller-Buhl U, Wiesemann A, Oser B, Kirchberger I and Strecker E P (1999) Correlation of hemodynamic and functional
variables with the angiographic extent of peripheral arterial occlusive disease. Vasc. Med.; 4: 247-251.
3. Yasojima K, Schwab C, McGeer E G and McGeer P L (2001) Generation of C-reactive protein and complement components
in atherosclerotic plaques. Am J Pathol.; 158: 1039- 1051.
4. Pasceri V, Willerson J T and Yeh E T (2000) Direct proinflammatory effect of C-reactive protein on human endothelial
cells. Circulation; 102: 2165-2168.
5. Pasceri V, Chang J, Willerson J T and Yeh E T (2001) Modulation of C-reactive protein mediated monocyte chemoattractant
protein-1 induction in human endothelial cells by anti-atherosclerosis drugs Circulation; 103: 2531-2534.
Aditya Vedula is a Resident of Internal Medicine with Aptitude for Diabetes and Nephrology in Sree Balaji Medical College in Chennai, India.
E-mail: adityavedula.1988@gmail.com
