Magdy I El-Zahar, Somaia S Abd El-Karim, Rasha S Gouhar, Mogedda E Haiba, Ghada E A Awad and Ola Bagato
Posters-Accepted Abstracts: Biol Syst Open Access
A new series of novel derivatives of tetrahydronaphthalene moiety conjugated with biologically active various side chains and heterocycles such as substituted pyrazole and/or substituted thiazole ring systems were synthesized and evaluated as antibacterial, antifungal and antiviral (H5N1) agents. The evaluation exhibited that analogue compound A and compound B produced the highest broad spectrum antibacterial activity against the tested Gram positive and Gram negative bacteria comparing to reference Clotrimazole drug. Antiviral evaluation of the novel derivatives exhibited moderate activity. More structural modifications are required to improve their antimicrobial potency.