Biological Systems: Open Access

ISSN - 2329-6577


Synthesis and antimicrobial, antiviral evaluation of novel derivatives heterocycles-tetrahydronaphthalene

3rd International Conference on Integrative Biology

August 04-06, 2015 Valencia, Spain

Magdy I El-Zahar, Somaia S Abd El-Karim, Rasha S Gouhar, Mogedda E Haiba, Ghada E A Awad and Ola Bagato

Posters-Accepted Abstracts: Biol Syst Open Access

Abstract :

A new series of novel derivatives of tetrahydronaphthalene moiety conjugated with biologically active various side chains and heterocycles such as substituted pyrazole and/or substituted thiazole ring systems were synthesized and evaluated as antibacterial, antifungal and antiviral (H5N1) agents. The evaluation exhibited that analogue compound A and compound B produced the highest broad spectrum antibacterial activity against the tested Gram positive and Gram negative bacteria comparing to reference Clotrimazole drug. Antiviral evaluation of the novel derivatives exhibited moderate activity. More structural modifications are required to improve their antimicrobial potency.