Salih Atalah Alenezi* , Nusaiba Elkmeshi, Abdullah Alanazi, Sulaiman T. Alanazi, Raheela Khan, Saad Amer
University of Nottingham, UK
Scientific Tracks Abstracts: J Steroid Horm Sci
Currently, the primary strategy for addressing polycystic ovarian syndrome (PCOS) involves lifestyle modifications, with a focus on weight loss. The purpose of this meta-analysis was to assess the impact of weight loss through dietary interventions on inflammatory status and hyperandrogenism in PCOS women. A comprehensive search was conducted to identify randomised controlled trials (RCTs) and cohort studies assessing the impact of diet-induced weight loss on circulating inflammatory markers (CRP, IL-6, IL-1ÃÂ?², TNF-ÃÂ?±), androgens (testosterone, SHBG, androstenedione) and luteinising hormone (LH) in PCOS women. The quality and risk of bias of the included studies were assessed using the Cochrane Collaboration's tool for RCTs and the Newcastleâ?? Ottawa Scale for cohort studies. Data were entered into RevMan software v5.9 for the calculation of standard mean difference (SMD) and 95% confidence interval (95%CI) of circulating inflammatory markers, androgens and LH between baseline and post-weight loss values. Eleven studies (n=298) were eligible for the systematic review, of which nine (n=261) were included in the meta-analysis. Pooled analysis of data revealed a statistically significant decrease in circulating CRP (SMD 0.55, 95%CI 0.09, 1.02; 9 studies, n=261), testosterone (SMD 0.46, 95%Cl, 0.08, 0.84; 6 studies, n=185), androstenedione (SMD 0.36, 95%Cl, 0.12, 0.60; 4 studies, n=143) and LH (SMD 0.36, 95% Cl, 0.14, 0.59; 5 studies, n=172) after weight loss compared to baseline levels among PCOS women. Meta-analysis of six studies (n=198) showed a statistically significant increase in circulating SHBG after weight loss compared to baseline levels (SMD -0.78, 95%Cl, -1.41, -0.14). These findings suggest that weight loss induced by dietary intervention seems to improve PCOS-related chronic inflammation and hyperandrogenism. The possible causative relationship between the improvement in inflammation and hyperandrogenism remains to be determined.
Salih is a dedicated full-time Clinical Lab Specialist at the Ministry of Health in the Kingdom of Saudi Arabia, also serving as a dedicated senior lab specialist at the regional laboratory in KSA. Salih is currently immersed in pursuing a PhD in Women's Infertility and Human Stem Cell Culturing at the School of Medicine, University of Nottingham, UK. This dual role allows him to seamlessly integrate hands-on experience in the clinical laboratory with cutting-edge research, aiming to advance our understanding of reproductive health and explore innovative solutions in stem cell biology.
