Biological Systems: Open Access

ISSN - 2329-6577


The retinoic acid receptor controls the mechanobiology in pancreatic stellate cells to suppress matrix remodeling and inhibit cancer cell invasion

4th International Conference on Integrative Biology

July 18-20, 2016 Berlin, Germany

Armando Del Rio Hernandez

Imperial College London, UK

Keynote: Biol syst Open Access

Abstract :

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with a 5-year survival rate of less than 4%. This rate has remained unchanged for the last 40 years despite advances in conventional therapies targeting cancer cells. PDAC tumors are characterized by remarkable matrix stiffness and a strong desmoplastic reaction that is mediated by the main cellular component in the tumor microenvironment pancreatic stellate cells (PSCs). Activated PSCs cross-talk with cancer cells to promote tumor growth, metastasis and chemoresistance, but the molecular mechanism that keeps PSCs persistently activated remains unknown. Our studies implicate retinoic acid receptor as a regulator of traction forces and mechanosensing in PSCs and this regulation influences the capacity of PSCs to migrate, to remodel the extracellular matrix (ECM) and to promote pancreatic cancer cell invasion.

Biography :

Armando Del Rio Hernandez has obtained his PhD in Chemistry from the Computense University in Madrid. Following this, he has completed a period of Postdoctoral training in the US. He has worked at Columbia University of New York as a Research Fellow first and later as a Research Associate. He currently leads the Cellular and Molecular Biomechanics group in the Department of Bioengineering at Imperial College London. He is a European Research Council Fellow and Editorial Board Member of several journals.