Shyamapada Mandal
University of Gour Banga, India
Scientific Tracks Abstracts: Gen Med (Los Angeles)
The monkeypox, a localized zoonotic disease in Central and West Africa due to the Monkey Pox Virus (MPXV) infection, is now a matter of global concern because of the (ongoing) multi-country outbreak in the rest of the world. An antiviral agent, Tecovirimat (TVM), designed to treat smallpox, is an FDA approved drug that is also licensed to treat monkeypox. However, due to the possible development of resistance to MPXV, TVM treatment failure of monkeypox might be anticipated. In order to check the antiviral efficacy of a plant-derived small molecule (myricetin; MRC) along with the standard drug TVM, against MPXV, molecular docking was performed between MPXV-based proteins (A42R profilin-like protein and MPXV-virulence protein) and the ligands (MRC and TVM), using AutoDock Vina. The binding energy (BE) of MRC to the A42R and virulence proteins were predicted as -7.8 and 7.0 kcal/mol, respectively, while the respective BE values for TVM were -9.0 and 7.6 kcal/mol. Furthermore, the acceptable ADMET profiles and Lipinski’s rule of five of MRC suggest the plant-based natural drug development with the studied compound for combating the monkeypox.
Shyamapada Mandal is Professor and Head of the Department of Zoology, and Dean (Science), University of Gour Banga, India. He is working on infectious diseases, probiotics, and genomics and bioinformatics research. He did pre-PhD, PhD, and post-PhD research under the guidance of Professor Nishith Kumar Pal at the Calcutta School of Tropical Medicine, India. He has published 118 articles with eight book chapters. He is life member of IAMM and IASR, India, and fellow member of SASS, India. Eight national academic and research awards have been conferred to him. He has guided 52 post graduate students; supervised three MPhil and three PhD students, and supervising 7 PhD and one MPhil students. Professor Mandal is among the world’s top 2% scientists as per the survey of the Stanford University, published in PLOS (Public Library of Science) Biology (October, 2020). He is featured in the top 2% world scientists list for second consecutive time as published by the Stanford University-Elsevier BV (October, 2021).
