Casper G Schalkwijk
Laboratory for Metabolism and Vascular Medicine, Maastricht University Medical Centre,
Peter Debeyelaan 25, P.O. Box 5800, 6202 AZ Maastricht
England
Research Article
Higher Plasma Concentrations of the Methylglyoxal Metabolite D-lactate are Independently Associated with Insulin Resistance: The CODAM Study
Author(s): Dionne EM Maessen, Jean LJM Scheijen, Katrien H Gaens, Marleen MJ van Greevenbroek, Carla J van der Kallen, Coen DA Stehouwer and Casper G SchalkwijkDionne EM Maessen, Jean LJM Scheijen, Katrien H Gaens, Marleen MJ van Greevenbroek, Carla J van der Kallen, Coen DA Stehouwer and Casper G Schalkwijk
Objective: Methylglyoxal (MGO), a highly reactive dicarbonyl compound generated by the spontaneous degradation of glycolytic intermediates, is a major precursor for advanced glycation endproducts and can potentially disrupt cellular functions. MGO can be detoxified by the glyoxalase system into D-lactate. Although experimental studies have shown that increased levels of MGO are associated with insulin resistance, epidemiological evidence of such an association in human studies is lacking. The aim of this study was to investigate the association between plasma D-lactate, as a reflection of plasma MGO concentrations, and insulin resistance. Methods: Cross-sectional, complete case analyses were performed in the Cohort study on Diabetes and Atherosclerosis Maastricht (CODAM). 513 participants were included in the study population: 59.4 ± 6.9 years of age, 63% men, and, by design, 2.. View More»
