Ningzhi Xu
Laboratory of Cell and Molecular Biology, Cancer Institute, Chinese Academy of Medical Science,
Beijing 100021
IR Iran
Review Article
Is Type 2 Diabetes One of Such Aging Phenomena That Lack an Irreversible Structural Change?
Author(s): Qingwen Jia, Xiaohan Chen, Yuping Jia, Xixi Dou, Lewis Ezeogu, Ningzhi Xu and D Joshua LiaoQingwen Jia, Xiaohan Chen, Yuping Jia, Xixi Dou, Lewis Ezeogu, Ningzhi Xu and D Joshua Liao
All biological functions should have a structural basis. Any functional change should be due to an alteration in the related structure. If a functional change is irreversible, it should be due to the irreversibility of the structural alteration. For instance, cancer is irreversible because cancer cells have irreversible genetic mutations. However, Type 2 Diabetes (T2D) with Insulin-Resistance (IR) as a central mechanism is irreversible but seems to lack a corresponding irreversible structural change. IR and T2D exhibit many abnormalities that are attributable to altered mitochondria or altered cellular RNAs, proteins, lipids, etc. without genetic mutations involved. These alterations are reversible, because mitochondrial biogenesis can be induced by such as exercise whereas RNAs, proteins and lipids will degrade after some time. Aging is irreversible but many aging ma.. View More»
