Paras Kumar Mishra
668 S 41st Street, DRC1, Room 5047, Omaha, NE-68198-5850
Tanzania
Editorial
Is Mir-133a a Promising Therapeutic Target for Heart Failure?
Author(s): Paras Kumar MishraParas Kumar Mishra
Although miR-133 mitigates cardiac hypertrophy and fibrosis, fine tunes β1-AR signaling, and protects against oxidative stress mediated apoptosis, it is unclear whether overexpression of miR-133a can ameliorate left ventricular function in failing hearts. Considering its multidisciplinary role in the heart, it is suggested that miR-133a is a master regulator of several networks that controls pathological cardiac remodeling. Therefore, it is a promising therapeutic target for heart failure.
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