Prasad Dhurjati
Tanzania
Research Article
Development of Physiologically Based Pharmacokinetic Model (PBPK) of BMP2 in Mice
Author(s): Aditya Utturkar, Bikram Paul, Hemanth Akkiraju, Jeremy Bonor, Prasad Dhurjati and Anja NoheAditya Utturkar, Bikram Paul, Hemanth Akkiraju, Jeremy Bonor, Prasad Dhurjati and Anja Nohe
Bone Morphogenetic protein 2 holds great promise for potential applications in the clinic. It is a potent growth factor for the use in the cervical spine surgery (FDA approved 2002) and has been marketed as “Infuse” for treating open tibial shaft fractures (FDA approved 2004). However, its use is limited by several significant side effects that maybe due to its potency and effect on different stem cell populations in the spine. BMP2 is expressed throughout the human body in several tissues and at a very high concentration in the blood. BMP receptors, especially BMP receptor type Ia, is ubiquitously expressed in most tissues. Currently, it is difficult to determine how BMP2 is physiologically distributed in mice or humans and no quantitative models are available.
A Physiologically-Based Pharmaco-Kinetic (PBPK) model has been developed to determine steady-state dis.. View More»
