Ryutaro Numaguchi
Japan
Research Article
Leptin is Associated with Local Stiffness of the Carotid Artery in Overweight Patients with Type 2 Diabetes
Author(s): Ryutaro Numaguchi, Tomoaki Morioka, Yuko Yamazaki, Satoshi Imamura, Hiromi Urata, Koka Motoyama, Katsuhito Mori, Katsuhito Mori, Shinya Fukumoto, Tetsuo Shoji, Masanori Emoto and Masaaki InabaRyutaro Numaguchi, Tomoaki Morioka, Yuko Yamazaki, Satoshi Imamura, Hiromi Urata, Koka Motoyama, Katsuhito Mori, Katsuhito Mori, Shinya Fukumoto, Tetsuo Shoji, Masanori Emoto and Masaaki Inaba
Objective: Besides its major role in the regulation of food intake and energy expenditure, leptin is involved in the pathogenesis of obesity-associated atherosclerosis. However, the clinical association between leptin and arterial stiffness, a surrogate marker for cardiovascular disease, has not been fully elucidated. This study aimed to investigate the association between the plasma leptin level and arterial stiffness in patients with type 2 diabetes.
Methods: Three hundred eighteen patients with type 2 diabetes, of which 155 were overweight (body mass index ≥ 25 kg/m2), were included in this study. Fasting plasma leptin levels were measured by enzyme-linked immunosorbent assay. Stiffness of the common carotid artery was evaluated by ultrasonography using Peterson’s elastic modulus (Ep) and arterial compliance (AC). A.. View More»
