Toshitaka Umemura
Japan
Research Article
Factors Associated with Brain Atrophy Estimated with Automatic Voxel- Based Morphometry of Structural Magnetic Resonance Images in Elderly Diabetic Patients: Impact of Albuminuria on Hippocampal Atrophy
Author(s): Takahiko Kawamura, Toshitaka Umemura, Rui Imamine, Hiroyuki Umegaki, Naoko Kawano, Asako Mizoguchi, Mariko Kawai, Makiko Minatoguchi, Minoru Kusama, Yu Kouchi, Atsuko Watarai, Akio Kanai, Eitaro Nakashima and Nigishi HottaTakahiko Kawamura, Toshitaka Umemura, Rui Imamine, Hiroyuki Umegaki, Naoko Kawano, Asako Mizoguchi, Mariko Kawai, Makiko Minatoguchi, Minoru Kusama, Yu Kouchi, Atsuko Watarai, Akio Kanai, Eitaro Nakashima and Nigishi Hotta
Background: We investigated what factors were associated with brain atrophy in elderly patients with type 2 diabetes.
Methods: We evaluated hippocampal and whole brain atrophy with automatic voxel-based morphometry of structural magnetic resonance image (MRI), voxel-based specific analysis regional analysis for Alzheimer’s disease (VSRAD), in 70 diabetic subjects and 35 non-diabetic subjects. Cognitive function tests – MMSE, word recall (immediate and delayed), Digit Symbol Substitution test (DSST), and Stroop Color Word (Stroop) test were performed. Cerebral small vessel disease (SVD) was diagnosed as silent brain infarct and white matter lesions (WMLs) according to MRI.
Results: Significantly stronger hippocampal and whole brain atrophy were observed in diabetic patie.. View More»
