Journal of Diabetes & Metabolism

ISSN - 2155-6156

Yu-Long Li

Yu-Long Li
University of Nebraska Medical Center,
Omaha, NE 68198-5850
Tanzania

Publications
  • Review Article
    Angiotensin II-Superoxide Signaling and Arterial Baroreceptor Function in Type-1 Diabetes Mellitus
    Author(s): Yu-Long LiYu-Long Li

    Diabetes is a major world health problem. Growing evidence from both clinical trials and animal experiments has clearly confirmed that arterial baroreflex dysfunction is a feature of type 1 diabetes, which links to prognosis and mortality of the type 1 diabetic patients. The arterial baroreflex normally regulates the blood pressure and heart rate through sensing changes of arterial vascular tension by the arterial baroreceptors in the aortic arch and carotid sinus. The aortic baroreceptor neuron located in the nodose ganglia is a primary afferent component of the arterial baroreflex. The functional changes of these neurons are involved in the arterial baroreflex dysfunction in the type 1 diabetes. Type 1 diabetes causes the overexpression and hyperactivation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and further reduces cell excitability of the aortic barore.. View More»

    DOI: 10.4172/2155-6156.S12-001

    Abstract PDF

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