Department of Endocrinology, University of Khartoum, Sudan
Commentary
Exploring the Interplay Between Gut Microbiota and Metabolic Health in Diabetes
Author(s): Ahmed Yasin El-Tayeb*
The human gut microbiota, comprising trillions of microorganisms, plays
a pivotal role in maintaining metabolic homeostasis. Increasing evidence
suggests that dysbiosis, or an imbalance in the gut microbiota, is intricately
linked to the pathogenesis of type 2 diabetes mellitus (T2DM). This article
explores the complex relationship between gut microbial composition
and metabolic health, focusing on how microbial metabolites influence
glucose metabolism, insulin sensitivity, and systemic inflammation.
Key findings highlight alterations in specific microbial taxa in diabetic
individuals, the impact of short-chain fatty acids (SCFAs), endotoxins
like lipopolysaccharides (LPS), and gut barrier function. Understanding
these interactions provides promising avenues for therapeutic strategies
including prebiotics, probiotics, and fecal microbiota transplantation... View More»
