Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Ahmadu Bello University Zaria, Kaduna, Nigeria
Research Article
Evaluation of Oral Administration of Lauric Acid Supplement on Fasting Blood Glucose Level and Pancreatic Histomorphological Studies in High Fat Diet/Streptozotocin-Induced Type 2 Diabetic Male Wistar Rats
Author(s): EA Alex*, AB Dubo, DC Ejiogu, KW Iyomo, KV Jerome, ND Aisha, AO Daikwo, J Yahaya, JD Yaro and RO Osiyemi
Background: Diabetes mellitus is the most common serious metabolic disease in human with a hall-mark of an elevated blood glucose concentration caused by a number of biochemical and physiological alterations
Aim: The aim of the study was to evaluate the effect oral administration of lauric acid supplement on fasting blood glucose level and pancreatic histomorphological studies in high fat diet/streptozotocin (STZ)-induced type 2 diabetic male Wistar rats.
Study Design: Thirty-five apparently healthy male Wistar rats of 6-8 weeks, weighing between 70 g-90 g were grouped into seven groups of five animals each (n=5) and treated for a period of twenty-one days (21) with graded doses of lauric acid supplement after validation of diabetes. Group 1 and 3 were fed with normal rat feed while group 2, 4, 5, 6, 7 were fed with hi.. View More»
DOI:
10.35248/2155-6156.20.11.849
