Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria
Research Article
Evaluation of Oral Administration of Lauric Acid Supplement on Fasting Blood Glucose Level and Pancreatic Histomorphological Studies in High Fat Diet/Streptozotocin-Induced Type 2 Diabetic Male Wistar Rats
Author(s): EA Alex*, AB Dubo, DC Ejiogu, KW Iyomo, KV Jerome, ND Aisha, AO Daikwo, J Yahaya, JD Yaro and RO Osiyemi
Background: Diabetes mellitus is the most common serious metabolic disease in human with a hall-mark of an elevated blood glucose concentration caused by a number of biochemical and physiological alterations
Aim: The aim of the study was to evaluate the effect oral administration of lauric acid supplement on fasting blood glucose level and pancreatic histomorphological studies in high fat diet/streptozotocin (STZ)-induced type 2 diabetic male Wistar rats.
Study Design: Thirty-five apparently healthy male Wistar rats of 6-8 weeks, weighing between 70 g-90 g were grouped into seven groups of five animals each (n=5) and treated for a period of twenty-one days (21) with graded doses of lauric acid supplement after validation of diabetes. Group 1 and 3 were fed with normal rat feed while group 2, 4, 5, 6, 7 were fed with hi.. View More»
DOI:
10.35248/2155-6156.20.11.849
