Division of Diabetes & Metabolic Disorders, Makerere University, Uganda
Opinion
Pathophysiology, Clinical Impact, and Emerging Therapeutic Strategies of Metabolic Dysfunction
Author(s): Joseph Mugisha*
Metabolic dysfunction is a complex condition characterized by disruptions in fundamental biochemical pathways that regulate energy homeostasis, glucose metabolism, and lipid balance. It is a hallmark of several metabolic disorders, including obesity, Type 2 Diabetes Mellitus (T2DM), and metabolic syndrome. These dysfunctions arise due to a combination of genetic predisposition, lifestyle factors, and environmental influences. Insulin resistance, chronic inflammation, and mitochondrial abnormalities are key contributors to metabolic impairment. The clinical implications of metabolic dysfunction are extensive, leading to an increased risk of cardiovascular diseases, neurodegenerative disorders, and Non-Alcoholic Fatty Liver Disease (NAFLD). Understanding the underlying mechanisms is crucial for developing effective therapeutic strategies, ranging from pharmacological interventions to li.. View More»
